Low incidence of lymphoproliferative disease post kidney transplantation with prevalent use of alemtuzumab

  • John Fredy Nieto-Ríos Sección Nefrología y Trasplante Renal, Hospital Pablo Tobón Uribe, Medellín
  • Arbey Aristizabal-Alzate Sección Nefrología y Trasplante Renal, Hospital Pablo Tobón Uribe, Medellín
  • Catalina Ocampo-Kohn Sección Nefrología y Trasplante Renal, Hospital Pablo Tobón Uribe, Medellín
  • Juan José Vanegas-Ruiz Sección Nefrología y Trasplante Renal, Hospital Pablo Tobón Uribe, Medellín
  • Catalina Vélez-Echeverri Sección Nefrología y Trasplante Renal, Hospital Pablo Tobón Uribe, Medellín
  • Lina María Serna-Higuita Sección Nefrología y Trasplante Renal, Hospital Pablo Tobón Uribe, Medellín
  • Daniel Camilo Aguirre Instituto de Investigaciones Médicas, Universidad de Antioquia, Antioquía
  • Carlos Enrique Yepes-Delgado Sección de investigación, Hospital Pablo Tobón Uribe, Medellín
  • Gustavo Zuluaga-Valencia Sección Nefrología y Trasplante Renal, Hospital Pablo Tobón Uribe, Medellín
Keywords: Post transplant lymphoproliferative disease, PTLD, renal transplant, alemtuzumab

Abstract

Introduction: It is well known that the incidence of malignancy is significantly higher in transplanted patients than in general population. The incidence of lymphoproliferative disease post-transplantation (PTLD) is approximately of 1% to 2% in kidney transplantation recipients. Objective: The main objective of this study was to evaluate the PTLD incidence when monitoring kidney transplanted patients between the years 2005 and 2010. Methods: Kidney transplanted patients’ data was retrospectively taken between the years 2005 to 2010 in order to determine the number of PTLD cases according to the inductor scheme used. Results: 425 patients were transplanted between 2005 and 2010. They received alemtuzumab 76.2%, daclizumab 10.7%, basiliximab 3.6% and thymoglobulin 2.4%. The 7% did not receive antibody induction. During this period 2 cases of PTLD ocurred: One with multiple myeloma and the other with lymphoma. One of them had been treated with alemtuzumab and the other with thymoglobulin. Conclusions: The PTLD incidence in our group, where alemtuzumab was used predominantly as inductor, was very low; this might suggest that alemtuzumab is a medication that does not increase the risk of this kind of neoplasia.

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Published
2014-01-01
How to Cite
1.
Nieto-Ríos JF, Aristizabal-Alzate A, Ocampo-Kohn C, Vanegas-Ruiz JJ, Vélez-Echeverri C, Serna-Higuita LM, Aguirre DC, Yepes-Delgado CE, Zuluaga-Valencia G. Low incidence of lymphoproliferative disease post kidney transplantation with prevalent use of alemtuzumab. Rev Nefrol Dial Traspl. [Internet]. 2014Jan.1 [cited 2024Nov.25];34(1):21-6. Available from: http://revistarenal.org.ar/index.php/rndt/article/view/99
Issue
Vol. 34 No. 1 (2014): Ene.-Mar.
Section
Original Article