Peritoneal dialysis related peritonitis; a single center results

Abstract

Introduction: Peritoneal dialysis (PD) related peritonitis is one of the most serious complications which leads to technical failure, transfer to hemodialysis and mortality. Objective: We aimed to evaluate peritonitis rate, clinical outcome, and mortality in PD patients’ 10-year follow-up. Methods: PD-related peritonitis period of 2009 to 2018 were analyzed, retrospectively. Demographic features, causative microorganism, antibiotic resistance, and biochemical parameters were obtained from hospital records. Catheter removal, mortality and peritonitis rate results were evaluated. Results: A total of 80 PD-related peritonitis was detected. The overall peritonitis rate was 0.24 episode/year, annually was ranging from 0.14 to 0.53. Gram-positive, gram-negative and culture negative peritonitis rate was 58.8%, 21.3%, %18.8, respectively. Coagulase negative staphylococcus (30%) was the most common causative microorganism and 37.5% of them were methicillin-resistant, while 100% of Staphylococcus aureus were sensitive to methicillin. Peritoneal effluent leukocyte count at admission was significantly higher in gram-negative than gram-positive peritonitis. Peritonitis-associated catheter removal and mortality rate were 26.25% and 6.25%, respectively. C-reactive protein 0^th and 3^rd day, peritoneal effluent leukocytes and neutrophils 3rd day count were significantly higher and total protein and albumin 0th and 3rd day results were significantly lower in catheter removed patients. The catheter removal was significantly higher in female patients and in gram-negative peritonitis. It was found that decrease in 1g/dL of albumin increases the probability of catheter removal by 13.8 fold. Conclusion: Catheter removal was slightly elevated at our center. Catheter loss was associated with female gender, gram-negative strains, and hypoalbuminemia in PD-related peritonitis.