Recurrent urinary tract infections: Predisposing factors and antibiotic prophylaxis

Abstract

Introduction: Some predisposing factors and the administration of antibiotic prophylaxis can influence recurrent urinary tract infections. Objectives: 1) To evaluate the incidence of the urinary tract infections episodes with and without antibiotic prophylaxis; 2) To evaluate the relation between the predisposing factors (dysfunctional elimination syndrome, oxiuriasis, and hypercalciuria), and the recurrence of the urinary tract infections. Methods: It was a prospective, not blinded randomized clinical study with a cohort of 50 patients (mean age 4.6 years) with normal renal function, and without any other urological or neprhological pathology. In all patients were treated the predisposing factors. Results: Group A, 26 patients (with antibiotic prophylaxis). Incidence rate of the urinary tract infections: 15/100 patients-month;; mean value when entering the study 3. 6, and when the study was finished, 2. Group B, 24 patients (without antibiotic prophylaxis). Incidence rate of the urinary tract infections: 14.5/100 patients-month;; mean value when entering the study 3.5, and when the study was finished, 2.1. X 2: 0.0524 (p: 0.81). The more
affected patients were the girls between 3 and 4 years old (71%). Months of greater incidence were May to October. Associated factor to exposition (predisposing factors): 68%, Coefficient of correlation: 0.7. With regard to the proportional risks model, the predisposing factors with significantly relative risk were the dysfunctional elimination syndrome (without neither encopresis nor constipation), and hypercalciuria. Conclusions: 1) The antibiotic prophylaxis did not reduce significantly the infectious recurrences; 2) The control of the predisposing factors could reduce the frequency of the urinary tract infections.