Relationship between renal function and bone mineral density in kidney transplant recipients

  • María del Cármen López Ruiz Departamento de Ciencias de la Salud, Universidad de Jaén, Jaén
  • Rafael Fernández Castillo Servicio de Nefrología, Hospital Universitario Virgen de las Nieves, Granada
  • Rafael José Esteban De la Rosa Servicio de Nefrología, Hospital Universitario Virgen de las Nieves, Granada
  • Ana Raquel Ortega Martínez Departamento de Ciencias de la Salud, Universidad de Jaén, Jaén
  • Juan Antonio Bravo Soto Servicio de Nefrología, Hospital Universitario Virgen de las Nieves, Granada
Keywords: kidney function tests, renal function, bone mineral density, bone mass, glomerular filtration rate, diet, postransplant

Abstract

Background and objective: To study the relationship between measures of renal function and bone mineral density (BMD) to determine which measure of renal function by Cockcroft-Gault (CG) and estimated glomerular filtration rate by modification of diet in renal disease (MDRD), is more strongly associated with bone mineral density(BMI). Methods: The sample consisted of 310 patients transplanted, 194 men and 116 women, which underwent measurement of bone mineral density in lumbar spine, femur and radioulnar Rx dual absorptiometry (DXA) and renal function estimation by CG and MDRD methods and measurements of body mass index (BMI). Results: Mean bone mineral density and the CG and MDRD filtered, increase after 6 months the first year of transplantation in patients with normal bone mineral density, decreases in osteopenia and osteoporosis increases. BMI measurements were highly correlated with CG filtering the sixth month of transplantation (r = 0.222 p <0.001) and year (r = 0.258 p <0.001). Conclusions: Cockcroft-Gault (CG) and glomerular filtration rate estimated by the Modification of Diet in Renal Disease (MDRD) showed a high association with bone mineral density, but just the renal function as measured by CG is a predictor significant bone loss and fractures.

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Published
2017-10-31
How to Cite
1.
López Ruiz M del C, Fernández Castillo R, De la Rosa RJE, Ortega Martínez AR, Bravo Soto JA. Relationship between renal function and bone mineral density in kidney transplant recipients. Rev Nefrol Dial Traspl. [Internet]. 2017Oct.31 [cited 2024Jul.16];32(1):41-6. Available from: http://revistarenal.org.ar/index.php/rndt/article/view/193
Issue
Vol. 32 No. 1 (2012): Ene.-Mar.
Section
Original Article