TINU syndrome: a probably underdiagnosed entity

Antonio Rosales-Castillo Servicio de Medicina Interna, Hospital Universitario Virgen de las Nieves, Granada, España
Antonio Bustos-Merlo Servicio de Medicina Interna, Hospital Universitario Virgen de las Nieves, Granada, España
María del Pilar Aguilar Jaldo Servicio de Medicina Interna, Hospital Universitario Clínico San Cecilio, Granada, España

Keywords: uveitis, tubulointerstitial nephritis

Abstract

TINU syndrome (tubulointerstitial nephritis and uveitis) is a rare entity first described in 1975 by Dobrin et al. Since then, about 300 cases have been described in the literature. It typically affects children and adolescents with a clear predominance in women (9:1 in some studies). This disease consists of the association of systemic inflammatory syndrome, with an increase in acute phase reactants, proximal tubulo-interstitial nephropathy (glucosuria, leukocyturia) and non-granulomatous bilateral anterior uveitis, in most cases. We present a case of this entity with favorable evolution and therapeutic response. The initial symptoms were nonspecific, but there was a significant deterioration in renal function, for which steroid treatment was carried out with a successful response and without new relapses during follow-up.

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Published

2022-06-15

How to Cite

Rosales-Castillo A, Bustos-Merlo A, Aguilar Jaldo M del P. TINU syndrome: a probably underdiagnosed entity. Rev Nefrol Dial Traspl. [Internet]. 2022Jun.15 [cited 2024Sep.1];42(2):149-52. Available from: http://revistarenal.org.ar/index.php/rndt/article/view/793

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Issue

Vol. 42 No. 2 (2022): Abr.-Jun.

Section

Case Report

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