TINU syndrome: a probably underdiagnosed entity
Abstract
TINU syndrome (tubulointerstitial nephritis and uveitis) is a rare entity first described in 1975 by Dobrin et al. Since then, about 300 cases have been described in the literature. It typically affects children and adolescents with a clear predominance in women (9:1 in some studies). This disease consists of the association of systemic inflammatory syndrome, with an increase in acute phase reactants, proximal tubulo-interstitial nephropathy (glucosuria, leukocyturia) and non-granulomatous bilateral anterior uveitis, in most cases. We present a case of this entity with favorable evolution and therapeutic response. The initial symptoms were nonspecific, but there was a significant deterioration in renal function, for which steroid treatment was carried out with a successful response and without new relapses during follow-up.
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