Membranous paraneoplastic nephropathy due to solitary pulmonary nodule in a young patient
Abstract
A solitary pulmonary nodule is defined as a rounded opacity that can measure up to 3 cm and is surrounded by healthy lung parenchyma. Its prevalence ranges from 2-24% in the non-investigated population and most of these have a benign course, requiring a differential diagnosis with neoplasms, infections, congenital and vascular origins.
The relationship between oncological pathologies and renal manifestations in the form of paraneoplastic syndromes has been widely described in the literature since its first reports almost 100 years ago. Among the paraneoplastic glomerulopathies, membranous nephropathy is the one most associated with the development of solid tumors among those most frequently described in the lung, gastrointestinal tract, and prostate. It is suggested that its origin is based on the response generated by the products formed from tumor cells.
The case of a patient with a diagnosis of solitary pulmonary nodule who develops nephrotic syndrome is presented, confirming the presence of membranous nephropathy by renal biopsy. Due to presenting a positive anti PLA2R and the cause not being found in complementary studies, surgical extraction of the solitary pulmonary nodule was performed with which the remission of the condition was achieved.
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