Serum creatinine. From clinical practice to epidemiology through determination standards and quality control across clinical laboratories

  • Ana María Cusumano Centro de Educación Médica e Investigaciones Clínicas, CEMIC, Buenos Aires
  • Gustavo A. Velasco Fundación Renal del Nordeste Argentino, Resistencia, Chaco
  • María Eugenia Bianchi Laboratorio de Análisis Clínicos, Hospital Dr. Julio C. Perrando, Resistencia, Chaco
  • Candela Torres Sistema de Estudio e Intervención de las Poblaciones con Riesgo de Desarrollar Enfermedad Renal (SIERC), Facultad de Medicina, Universidad Nacional del Nordeste, Corrientes
  • Romina Ceci Laboratorio de Referencia y Estandarización en Química Clínica (LARESBIC), Fundación Bioquímica Argentina, La Plata, Buenos Aires
  • Daniel Mazziotta Laboratorio de Referencia y Estandarización en Química Clínica (LARESBIC), Fundación Bioquímica Argentina, La Plata, Buenos Aires
  • Felipe Inserra Hospital Universitario Austral, Buenos Aires
Keywords: glomerular filtration rate, serum creatinine standardization

Abstract

This article attempts to show why it is necessary to improve quality control of clinical laboratories and move toward standardization of serum creatinine to help improve clinical and epidemiological diagnosis of chronic kidney disease especially in Latin America. The role of clinical laboratory is to provide useful, reliable and reproducible information to be used in clinical practice, regardless of the methodology used and the intervening laboratory. For this, quality was implemented to improve the systematic and random errors in the determinations of clinical laboratories. Standardization programs are launched in 2006. Moreover serum creatinine and creatinine clearance joined the clinic, to be arrived at a milestone that was the determination of the estimated Glomerular Filtration Rate (eGFR) from formulas (MDRD and CKD-EPI). The need for standardization of the determination of creatinine was established in the Guide 4 KDOQUI in 2002. Regarding the determination of serum creatinine for estimating eGFR, a long way has come: from identification of the concept of clearance, its application to the determination of renal function, its use in the clinic for diagnosis, progression and prognosis, identifying it as an epidemiological indicator in population risk setting. In this context the need for standardization is established.

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Published
2016-09-01
How to Cite
1.
Cusumano AM, Velasco GA, Bianchi ME, Torres C, Ceci R, Mazziotta D, Inserra F. Serum creatinine. From clinical practice to epidemiology through determination standards and quality control across clinical laboratories. Rev Nefrol Dial Traspl. [Internet]. 2016Sep.1 [cited 2024Jul.16];36(3):187-96. Available from: http://revistarenal.org.ar/index.php/rndt/article/view/76
Issue
Vol. 36 No. 3 (2016): Jul.-Sept.
Section
Review Article