Use of dynamometry in hemodialysis patients
Abstract
Introduction: Dynamometry is a cheap, simple and easily reproduced method to assess muscle strength (MS), which, like other processes of obtaining measurements, displays high sensitivity and specificity for the early detection of any change in the nutritional status. Objectives: To evaluate factors concerning the reduction in MS in patients undergoing hemodialysis (HD). Methods: A single center, crosssectional study was carried out. The following clinical variables were analyzed: sex, age, blood pressure, weight, significant weight loss within the last 36 months, body mass index (BMI), weight gain in between dialysis sessions, hemodialysis treatment time, diabetes, energy and protein intake. Other factors taken into account were: laboratory findings (hemoglobin, hepatogram, electrolyte panel, calcium test, phosphate test, lipid profile, protein analysis, transferrin saturation) and hand grip strength (before and after dialysis, on both arms) measured through dynamometry. The patients' muscle strength values were compared to those of healthy subjects. Values below the 10th percentile were regarded as abnormal. Mean, median, standard deviation as well as the X2 and the Student's t tests were considered where applicable. A p<0.05 constituted a significant value. Results: There were 73 patients included in this study and 47.95% of them showed low MS with significant strength loss on the arm having the vascular access when compared to the other arm (p 0.00019). A longer hemodialysis treatment time (p 0.026) and a lower BMI (p 0.046) were found to be the two variables with the highest impact on MS. Conclusions: Muscle strength loss in patients undergoing hemodialysis is very common and is associated with a longer HD treatment time and a lower BMI.
References
Schlüssel MM, Dos Anjos LA, Kac G. A dinamometria manual e seu uso na avaliação nutricional. Rev Nutr. 2008;21(2):223-35.
Kopple JD. McCollum Award Lecture, 1996: protein-energy malnutrition in maintenance dialysis patients. Am J Clin Nutr. 1997;65(5):1544-57.
Mehrotra R, Kopple JD. Nutritional management of maintenance dialysis patients: why aren’t we doing better? Annu Rev Nutr. 2001;21:343-79.
Kalantar-Zadeh K, Ikizler TA, Block G, Avram M, Kopple JD. Malnutrition-inflammation complex syndrome in dialysis patients: causes and consequences. Am J Kidney Dis. 2003;42(5):864-81.
Fouque D, Kalantar-Zadeh K, Kopple J, Cano N, Chauveau P, Cuppari L, et al. A proposed nomenclature and diagnostic criteria for protein–energy wasting in acute and chronic kidney disease. Kidney Int. 2008;73(4):391-8.
Ordóñez Pérez V, Barranco Hernández E, Guerra Bustillo G, Barreto Penié J, Santana Porbén S, Espinosa Borrás A, et al. Estado nutricional de los pacientes con insuficiencia renal crónica atendidos en el programa de Hemodiálisis del Hospital Clínico-Quirúrgico “Hermanos Ameijeiras”. Nutr Hosp. 2007;22(6):677-94.
Kopple JD. Abnormal amino acid and protein metabolism in uremia. Kidney Int. 1978;14(4):340-8.
Meuwese CL, Snaedal S, Halbesma N, Stenvikel P, Dekker FW, Qureshi AR et al. Trimestral variations of Creactive protein, interleukin-6 and tumor necrosis factor-α are similarly associated with survival in haemodialysis patients. Nephrol Dial Transplant. 2011;26(4):1313-8.
Normam K, Schutz T, Kemps M, Josef Lübke H, Lochs H, Pirlich M. The Subjective Global Assessment reliably identifies malnutrition-related muscle dysfunction. Clin Nutr. 2005;24(1):143-50.
Fernández Soto ML, González Jiménez A. Valoración y soporte nutricional en la enfermedad renal crónica. Nutr Clin Med. 2014;8(3):136-53.
Leal VO, Stockler-Pinto MB, Farage NE, Aranha LN, Fouque D, Anjos LA, et al. Handgrip strength and its dialysis determinants in hemodialysis patients. Nutrition. 2011;27(11-12):1125-9.
Gracia-Iguacel C, González-Parra E, Barril-Cuadrado G, Sánchez R, Egido J, Ortiz-Arduán A, et al. Definiendo el síndrome de desgaste proteico energético en la enfermedad renal crónica: prevalencia e implicaciones clínicas. Nefrología. 2014;34(4):507-19.
Schlüssel MM, Dos Anjos LA, De Vasconcellos MT, Kac G. Reference values of handgrip dynamometry of healthy adults: a population-based study. Clin Nutr. 2008;27(4):601-7.
Johansen KL, Kaysen GA, Young BS, Hung AM, Da Silva M, Chertow GM. Longitudinal study of nutritional status, body composition, and physical function in hemodialysis patients. Am J Clin Nutr. 2003;77(4):842-6.
Iseki K, Tozawa M, Takishita S. Effect of the duration of dialysis on survival in a cohort of chronic haemodialysis patients. Nephrol Dial Transplant. 2003;18(4):782-7.
Chertow GM, Johansen KL, Lew N, Lazarus JM, Lowrie EG. Vintage, nutritional status, and survival in hemodialysis patients. Kidney Int. 2000;57(3):1176-81.
Kerr A, Syddall HE, Cooper C, Turner GF, Briggs RS, Sayer AA. Does admission grip strength predict length of stay in hospitalised older patients? Age Ageing. 2006;35(1):82-4.
Guerra RS, Fonseca I, Pichel, F, Restivo MT, Amaral TF. Usefulness of six diagnostic and screening measures for undernutrition in predicting length of hospital stay: a comparative analysis. J Acad Nutr Diet. 2015;115(6):927-38.
Legrand D, Vaes B, Matheï C, Adriaensen W, Van Pottelbergh G, Degryse JM. Muscle strength and physical performance as predictors of mortality, hospitalization, and disability in the oldest old. J Am Geriatr Soc. 2014;62(6):1030-8.
Rantanen T, Guralnik JM, Foley D, et al. midlife handgrip strength as a predictor of old age disability. JAMA 1999; 281: 558-60.
Rantanen T, Harris T, Leveille SG, Visser M, Foley D, Masaki K, et al. Muscle strength and body mass index as long-term predictors of mortality in initially healthy men. J Gerontol A Biol Sci Med Sci. 2000;55(3):M168-73.
Laukkanen P, Heikkinen E, Kauppinen M. Muscle strength and mobility as predictors of survival in 75-84-year-old people. Age Ageing. 1995;24(6):468-73.
Leong DP, Teo KK, Rangarajan S, Lopez-Jaramillo P, Avezum A Jr, Orlandini A, et al. Prognostic value of grip strength: findings from the Prospective Urban Rural Epidemiology (PURE) study. Lancet. 2015;386(9990):266-73.