Inmunoglobulin G4-related kidney disease
Keywords:
inmunoglobulin G4, IgG4-related kidney disease, IgG4
Abstract
Immunoglobulin G4-related disease (IgG4-RD) is an immunomediated fibroinflammatory process. In the last few decades, this disease has been recognized as a systemic disorder encompassing individual involvement of organs, previously unrelated and known as independent entities.
Renal involvement in IgG4-RD may be both synchronous and metachronous to other organ compromise, such as that seen in autoimmune pancreatitis, sclerosing cholangitis, retroperitoneal fibrosis, or IgG4-related lymphadenopathy. In this review we present the most frequent manifestations of renal involvement due to IgG4-RD, highlighting the role of imaging tests. The treatment of both IgG4-RD in general and renal involvement in particular are glucocorticoids. It is important to know about this disease, be suspicious about it and make an early and accurate diagnosis.
References
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10) Mahajan VS, Mattoo H, Deshpande V, Pillai SS, Stone JH. IgG4-related disease. Annu Rev Pathol. 2014;9:315-47. doi: 10.1146/annurev-pathol-012513-104708.
11) Martínez-Valle F, Orozco-Gálvez O, Fernández-Codina A. Etiopatogenia, diagnóstico y tratamiento de la enfermedad relacionada con la IgG4. Med Clin (Barc). 2018;151(1):18-25. doi: 10.1016/j.medcli.2017.10.034.
12) Masaki Y, Dong L, Kurose N, Morikawa Y, Yamamoto M, Takahashi H, et al. Proposal for a new clinical entity, IgG4-positive multiorgan lymphoproliferative syndrome: analysis of 64 cases of IgG4-related disorders. Ann Rheum Dis. 2009;68(8):1310-5. doi: 10.1136/ard.2008.089169.
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14) Takano K, Yamamoto M, Takahashi H, Himi T. Recent advances in knowledge regarding the head and neck manifestations of IgG4-related disease. Auris Nasus Larynx. 2017;44(1):7-17. doi: 10.1016/j.anl.2016.10.011.
15) Stone JR. Aortitis, periaortitis, and retroperitoneal fibrosis, as manifestations of IgG4-related systemic disease. Curr Opin Rheumatol. 2011;23(1):88-94. doi: 10.1097/bor.0b013e3283412f7c.
16) Kuroda N, Nakamura S, Miyazaki K, Inoue K, Ohara M, Mizuno K, et al. Chronic sclerosing pyelitis with an increased number of IgG4-positive plasma cells. Med Mol Morphol. 2009;42(4):236-8. doi: 10.1007/s00795-008-0425-8.
17) Kim SA, Lee SR, Huh J, Shen SS, Ro JY. IgG4-associated inflammatory pseudotumor of ureter: clinicopathologic and immunohistochemical study of 3 cases. Hum Pathol. 2011;42(8):1178-84. doi: 10.1016/j.humpath.2010.03.011.
18) Nakai Y, Kagebayashi Y, Matsumoto Y, Fukui S, Kim Y, Yoshimoto S, et al. IgG4-related prostatitis associated with retroperitoneal fibrosis: a case report. Hinyokika Kiyo. 2013;59(12):781-4.
19) Yamaguchi Y, Kanetsuna Y, Honda K, Yamanaka N, Kawano M, Nagata M, et al. Characteristic tubulointerstitial nephritis in IgG4-related disease. Hum Pathol. 2012;43(4):536-49. doi: 10.1016/j.humpath.2011.06.002.
20) Fernández Lorente L, López Álvarez D, García López V, Abujder Kollros V, Ariza A, Gálvez A, et al. Enfermedad relacionada con IgG4: descripción de un caso con lesiones pulmonares, adenopatías mediastínicas e insuficiencia renal rápidamente progresiva. Nefrología (Madr.). 2015;35(2):218-23.
21) Kawano M, Saeki T, Nakashima H, Nishi S, Yamaguchi Y, Hisano S, et al. Proposal for diagnostic criteria for IgG4-related kidney disease. Clin Exp Nephrol. 2011;15(5):615-26. doi: 10.1007/s10157-011-0521-2.
22) Stone JH, Zen Y, Deshpande V. IgG4-related disease. N Engl J Med. 2012;366(6):539-51. doi: 10.1056/NEJMra1104650.
23) Wallace ZS, Mattoo H, Carruthers M, Vinay S Mahajan VS, Della Torre E, Lee H, et al. Plasmablasts as a biomarker for IgG4-related disease, independent of serum IgG4concentrations. Ann Rheum Dis. 2015;74(1):190-5. doi: 10.1136/annrheumdis-2014-205233.
24) Vasaitis L. IgG4-related disease: A relatively new concept for clinicians. Eur J Intern Med. 2016;27:1-9. doi: 10.1016/j.ejim.2015.09.022.
25) Stone JH, Brito-Zerón P, Bosch X, Ramos-Casals M. Diagnostic approach to the complexity of IgG4-Related disease. Mayo Clin Proc. 2015;90(7):927-39. doi: 10.1016/j.mayocp.2015.03.020.
26) Alexander MP, Larsen CP, Gibson IW, Nasr SH, Sethi S, Fidler ME, et al. Membranous glomerulonephritis is a manifestation of IgG4-related disease. Kidney Int. 2013;83(3):455-62. doi: 10.1038/ki.2012.382.
27) Al Zahrani H, Kyoung Kim T, Khalili K, Vlachou P, Yu H, Jang HJ. IgG4-related disease in the abdomen: a great mimicker. Semin Ultrasound CT MR. 2014;35(3):240-54. doi: 10.1053/j.sult.2013.12.002.
28) Watson SJ, Jenkins DA, Bellamy CO. Nephropathy in IgG4-related systemic disease. Am J Surg Pathol. 2006;30(11):1472-7. doi: 10.1097/01.pas.0000213308.43929.97.
29) Cornell LD, Chicano SL, Deshpande V, Collins AB, Selig MK, Lauwers GY, et al. Pseudotumors due to IgG4 immune-complex tubulointerstitial nephritis associated with autoimmune pancreatocentric disease. Am J Surg Pathol. 2007;31(10):1586-97. doi: 10.1097/PAS.0b013e318059b87c.
30) Kim B, Kim JH, Byun JH, Hyoung Jung Kim HJ, Lee SS, Kim SY, et al. IgG4-related kidney disease: MRI findings with emphasis on the usefulness of diffusion-weighted imaging. Eur J Radiol. 2014;83(7):1057-62. doi: 10.1016/j.ejrad.2014.03.033.
31) Sangha Brar JS, Gupta S, Haja Mohideen SM, Liauw L, Lath N. The pancreatic and extrapancreatic manifestations of IgG4-related disease. Diagn Interv Radiol. 2018;24(2):83-8. doi: 10.5152/dir.2018.17319.
32) Cortés-Romera M, Sabaté-Llobera A, Gámez-Cenzano C, Torras-Ambròs J. Utilidad de la PET/TC en la enfermedad por IgG4. Med Clin (Barc). 2015;145(7):321-2. doi: 10.1016/j.medcli.2014.11.019.
33) Raissian Y, Nasr SH, Larsen CP, Colvin RB, Smyrk TC, Takahashi N, et al. Diagnosis of IgG4-related tubulointerstitial nephritis. J Am Soc Nephrol. 2011;22(7):1343-52. doi: 10.1681/ASN.2011010062.
34) Saeki T, Kawano M. IgG4-related kidney disease [published correction appears in Kidney Int. 2014 Jun;85(6):1472]. Kidney Int. 2014;85(2):251-7. doi: 10.1038/ki.2013.393.
35) Yamaguchi Y, Kanetsuna Y, Honda K, Yamanaka N, Kawano M, Nagata M, et al. Characteristic tubulointerstitial nephritis in IgG4-related disease. Hum Pathol. 2012;43(4):536-49. doi: 10.1016/j.humpath.2011.06.002.
36) Sharma SG, Vlase HL, D'Agati VD. IgG4-related tubulointerstitial nephritis with plasma cell-rich renal arteritis. Am J Kidney Dis. 2013;61(4):638-43. doi: 10.1053/j.ajkd.2012.07.031.
37) Carruthers MN, Stone JH, Khosroshahi A. The latest on IgG4-RD: a rapidly emerging disease. Curr Opin Rheumatol. 2012;24(1):60-9. doi: 10.1097/BOR.0b013e32834ddb4a.
38) Okazaki K, Uchida K, Miyoshi H, Ikeura T, Takaoka M, Nishio A. Recent concepts of autoimmune pancreatitis and IgG4-related disease. Clin Rev Allergy Immunol. 2011;41(2):126-38. doi: 10.1007/s12016-010-8214-2.
39) Okazaki K, Uchida K, Koyabu M, Miyoshi H, Takaoka M. Recent advances in the concept and diagnosis of autoimmune pancreatitis and IgG4-related disease. J Gastroenterol. 2011;46(3):277-88. doi: 10.1007/s00535-011-0386-x.
40) Iaccarino L, Talarico R, Scirè CA, Amoura Z, Burmester G, Doria A, et al. IgG4-related diseases: state of the art on clinical practice guidelines. RMD Open. 2019;4(Suppl. 1):e000787. doi: 10.1136/rmdopen-2018-000787.
2) Kamisawa T, Zen Y, Pillai S, Stone JH. IgG4-related disease. Lancet. 2015;385(9976):1460-71. doi: 10.1016/S0140-6736(14)60720-0.
3) Yoshida K, Toki F, Takeuchi T, Watanabe S, Shiratori K, Hayashi N. Chronic pancreatitis caused by an autoimmune abnormality. Proposal of the concept of autoimmune pancreatitis. Dig Dis Sci. 1995;40(7):1561-8. doi: 10.1007/BF02285209.
4) Deshpande V, Zen Y, Chan JK, Yi EE, Sato Y, Yoshino T, et al. Consensus statement on the pathology of IgG4-related disease. Mod Pathol. 2012;25(9):1181-92. doi: 10.1038/modpathol.2012.72.
5) Uchiyama-Tanaka Y, Mori Y, Kimura T, Sonomura K, Umemura S, Kishimoto N, et al. Acute tubulointerstitial nephritis associated with autoimmune-related pancreatitis. Am J Kidney Dis. 2004;43(3):e18-e25. doi: 10.1053/j.ajkd.2003.12.006.
6) Saeki T, Nishi S, Imai N, Ito T, Yamazaki H, Kawano M, et al. Clinicopathological characteristics of patients with IgG4-related tubulointerstitial nephritis. Kidney Int. 2010;78(10):1016-23. doi: 10.1038/ki.2010.271.
7) Takahashi N, Kawashima A, Fletcher JG, Chari ST. Renal involvement in patients with autoimmune pancreatitis: CT and MR imaging findings. Radiology. 2007;242(3):791-801. doi: 10.1148/radiol.2423060003.
8) Khalili K, Doyle DJ, Chawla TP, Hanbidge AE. Renal cortical lesions in patients with autoimmune pancreatitis: a clue to differentiation from pancreatic malignancy. Eur J Radiol. 2008;67(2):329-35. doi: 10.1016/j.ejrad.2007.07.020.
9) Martínez-de-Alegría A, Baleato-González S, García-Figueiras R, Bermúdez-Naveira A, Abdulkader-Nallib I, Díaz-Peromingo JA, et al. IgG4-related Disease from Head to Toe. Radiographics. 2015;35(7):2007-25. doi: 10.1148/rg.357150066.
10) Mahajan VS, Mattoo H, Deshpande V, Pillai SS, Stone JH. IgG4-related disease. Annu Rev Pathol. 2014;9:315-47. doi: 10.1146/annurev-pathol-012513-104708.
11) Martínez-Valle F, Orozco-Gálvez O, Fernández-Codina A. Etiopatogenia, diagnóstico y tratamiento de la enfermedad relacionada con la IgG4. Med Clin (Barc). 2018;151(1):18-25. doi: 10.1016/j.medcli.2017.10.034.
12) Masaki Y, Dong L, Kurose N, Morikawa Y, Yamamoto M, Takahashi H, et al. Proposal for a new clinical entity, IgG4-positive multiorgan lymphoproliferative syndrome: analysis of 64 cases of IgG4-related disorders. Ann Rheum Dis. 2009;68(8):1310-5. doi: 10.1136/ard.2008.089169.
13) Baltar-Martin JM, García-Monteavaro C, Visus-Fernández-de Manzanos T, Parejo-García L. Afectación renal de las enfermedades relacionadas con IgG4. NefroPlus. 2015;7(1):1-10.
14) Takano K, Yamamoto M, Takahashi H, Himi T. Recent advances in knowledge regarding the head and neck manifestations of IgG4-related disease. Auris Nasus Larynx. 2017;44(1):7-17. doi: 10.1016/j.anl.2016.10.011.
15) Stone JR. Aortitis, periaortitis, and retroperitoneal fibrosis, as manifestations of IgG4-related systemic disease. Curr Opin Rheumatol. 2011;23(1):88-94. doi: 10.1097/bor.0b013e3283412f7c.
16) Kuroda N, Nakamura S, Miyazaki K, Inoue K, Ohara M, Mizuno K, et al. Chronic sclerosing pyelitis with an increased number of IgG4-positive plasma cells. Med Mol Morphol. 2009;42(4):236-8. doi: 10.1007/s00795-008-0425-8.
17) Kim SA, Lee SR, Huh J, Shen SS, Ro JY. IgG4-associated inflammatory pseudotumor of ureter: clinicopathologic and immunohistochemical study of 3 cases. Hum Pathol. 2011;42(8):1178-84. doi: 10.1016/j.humpath.2010.03.011.
18) Nakai Y, Kagebayashi Y, Matsumoto Y, Fukui S, Kim Y, Yoshimoto S, et al. IgG4-related prostatitis associated with retroperitoneal fibrosis: a case report. Hinyokika Kiyo. 2013;59(12):781-4.
19) Yamaguchi Y, Kanetsuna Y, Honda K, Yamanaka N, Kawano M, Nagata M, et al. Characteristic tubulointerstitial nephritis in IgG4-related disease. Hum Pathol. 2012;43(4):536-49. doi: 10.1016/j.humpath.2011.06.002.
20) Fernández Lorente L, López Álvarez D, García López V, Abujder Kollros V, Ariza A, Gálvez A, et al. Enfermedad relacionada con IgG4: descripción de un caso con lesiones pulmonares, adenopatías mediastínicas e insuficiencia renal rápidamente progresiva. Nefrología (Madr.). 2015;35(2):218-23.
21) Kawano M, Saeki T, Nakashima H, Nishi S, Yamaguchi Y, Hisano S, et al. Proposal for diagnostic criteria for IgG4-related kidney disease. Clin Exp Nephrol. 2011;15(5):615-26. doi: 10.1007/s10157-011-0521-2.
22) Stone JH, Zen Y, Deshpande V. IgG4-related disease. N Engl J Med. 2012;366(6):539-51. doi: 10.1056/NEJMra1104650.
23) Wallace ZS, Mattoo H, Carruthers M, Vinay S Mahajan VS, Della Torre E, Lee H, et al. Plasmablasts as a biomarker for IgG4-related disease, independent of serum IgG4concentrations. Ann Rheum Dis. 2015;74(1):190-5. doi: 10.1136/annrheumdis-2014-205233.
24) Vasaitis L. IgG4-related disease: A relatively new concept for clinicians. Eur J Intern Med. 2016;27:1-9. doi: 10.1016/j.ejim.2015.09.022.
25) Stone JH, Brito-Zerón P, Bosch X, Ramos-Casals M. Diagnostic approach to the complexity of IgG4-Related disease. Mayo Clin Proc. 2015;90(7):927-39. doi: 10.1016/j.mayocp.2015.03.020.
26) Alexander MP, Larsen CP, Gibson IW, Nasr SH, Sethi S, Fidler ME, et al. Membranous glomerulonephritis is a manifestation of IgG4-related disease. Kidney Int. 2013;83(3):455-62. doi: 10.1038/ki.2012.382.
27) Al Zahrani H, Kyoung Kim T, Khalili K, Vlachou P, Yu H, Jang HJ. IgG4-related disease in the abdomen: a great mimicker. Semin Ultrasound CT MR. 2014;35(3):240-54. doi: 10.1053/j.sult.2013.12.002.
28) Watson SJ, Jenkins DA, Bellamy CO. Nephropathy in IgG4-related systemic disease. Am J Surg Pathol. 2006;30(11):1472-7. doi: 10.1097/01.pas.0000213308.43929.97.
29) Cornell LD, Chicano SL, Deshpande V, Collins AB, Selig MK, Lauwers GY, et al. Pseudotumors due to IgG4 immune-complex tubulointerstitial nephritis associated with autoimmune pancreatocentric disease. Am J Surg Pathol. 2007;31(10):1586-97. doi: 10.1097/PAS.0b013e318059b87c.
30) Kim B, Kim JH, Byun JH, Hyoung Jung Kim HJ, Lee SS, Kim SY, et al. IgG4-related kidney disease: MRI findings with emphasis on the usefulness of diffusion-weighted imaging. Eur J Radiol. 2014;83(7):1057-62. doi: 10.1016/j.ejrad.2014.03.033.
31) Sangha Brar JS, Gupta S, Haja Mohideen SM, Liauw L, Lath N. The pancreatic and extrapancreatic manifestations of IgG4-related disease. Diagn Interv Radiol. 2018;24(2):83-8. doi: 10.5152/dir.2018.17319.
32) Cortés-Romera M, Sabaté-Llobera A, Gámez-Cenzano C, Torras-Ambròs J. Utilidad de la PET/TC en la enfermedad por IgG4. Med Clin (Barc). 2015;145(7):321-2. doi: 10.1016/j.medcli.2014.11.019.
33) Raissian Y, Nasr SH, Larsen CP, Colvin RB, Smyrk TC, Takahashi N, et al. Diagnosis of IgG4-related tubulointerstitial nephritis. J Am Soc Nephrol. 2011;22(7):1343-52. doi: 10.1681/ASN.2011010062.
34) Saeki T, Kawano M. IgG4-related kidney disease [published correction appears in Kidney Int. 2014 Jun;85(6):1472]. Kidney Int. 2014;85(2):251-7. doi: 10.1038/ki.2013.393.
35) Yamaguchi Y, Kanetsuna Y, Honda K, Yamanaka N, Kawano M, Nagata M, et al. Characteristic tubulointerstitial nephritis in IgG4-related disease. Hum Pathol. 2012;43(4):536-49. doi: 10.1016/j.humpath.2011.06.002.
36) Sharma SG, Vlase HL, D'Agati VD. IgG4-related tubulointerstitial nephritis with plasma cell-rich renal arteritis. Am J Kidney Dis. 2013;61(4):638-43. doi: 10.1053/j.ajkd.2012.07.031.
37) Carruthers MN, Stone JH, Khosroshahi A. The latest on IgG4-RD: a rapidly emerging disease. Curr Opin Rheumatol. 2012;24(1):60-9. doi: 10.1097/BOR.0b013e32834ddb4a.
38) Okazaki K, Uchida K, Miyoshi H, Ikeura T, Takaoka M, Nishio A. Recent concepts of autoimmune pancreatitis and IgG4-related disease. Clin Rev Allergy Immunol. 2011;41(2):126-38. doi: 10.1007/s12016-010-8214-2.
39) Okazaki K, Uchida K, Koyabu M, Miyoshi H, Takaoka M. Recent advances in the concept and diagnosis of autoimmune pancreatitis and IgG4-related disease. J Gastroenterol. 2011;46(3):277-88. doi: 10.1007/s00535-011-0386-x.
40) Iaccarino L, Talarico R, Scirè CA, Amoura Z, Burmester G, Doria A, et al. IgG4-related diseases: state of the art on clinical practice guidelines. RMD Open. 2019;4(Suppl. 1):e000787. doi: 10.1136/rmdopen-2018-000787.
Published
2020-12-15
How to Cite
1.
Sánchez Oro R, Alonso Muñóz EM. Inmunoglobulin G4-related kidney disease. Rev Nefrol Dial Traspl. [Internet]. 2020Dec.15 [cited 2024Nov.22];40(4):341-8. Available from: http://revistarenal.org.ar/index.php/rndt/article/view/577
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Review Article
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