Inmunoglobulin G4-related kidney disease
Keywords:
inmunoglobulin G4, IgG4-related kidney disease, IgG4
Abstract
Immunoglobulin G4-related disease (IgG4-RD) is an immunomediated fibroinflammatory process. In the last few decades, this disease has been recognized as a systemic disorder encompassing individual involvement of organs, previously unrelated and known as independent entities.
Renal involvement in IgG4-RD may be both synchronous and metachronous to other organ compromise, such as that seen in autoimmune pancreatitis, sclerosing cholangitis, retroperitoneal fibrosis, or IgG4-related lymphadenopathy. In this review we present the most frequent manifestations of renal involvement due to IgG4-RD, highlighting the role of imaging tests. The treatment of both IgG4-RD in general and renal involvement in particular are glucocorticoids. It is important to know about this disease, be suspicious about it and make an early and accurate diagnosis.
References
1) Khosroshahi A, Wallace ZS, Crowe JL, Akamizu T, Azumi A, Carruthers MN, et al. International Consensus Guidance Statement on the Management and Treatment of IgG4-Related Disease. Arthritis Rheumatol. 2015;67(7):1688-99. doi: 10.1002/art.39132.
2) Kamisawa T, Zen Y, Pillai S, Stone JH. IgG4-related disease. Lancet. 2015;385(9976):1460-71. doi: 10.1016/S0140-6736(14)60720-0.
3) Yoshida K, Toki F, Takeuchi T, Watanabe S, Shiratori K, Hayashi N. Chronic pancreatitis caused by an autoimmune abnormality. Proposal of the concept of autoimmune pancreatitis. Dig Dis Sci. 1995;40(7):1561-8. doi: 10.1007/BF02285209.
4) Deshpande V, Zen Y, Chan JK, Yi EE, Sato Y, Yoshino T, et al. Consensus statement on the pathology of IgG4-related disease. Mod Pathol. 2012;25(9):1181-92. doi: 10.1038/modpathol.2012.72.
5) Uchiyama-Tanaka Y, Mori Y, Kimura T, Sonomura K, Umemura S, Kishimoto N, et al. Acute tubulointerstitial nephritis associated with autoimmune-related pancreatitis. Am J Kidney Dis. 2004;43(3):e18-e25. doi: 10.1053/j.ajkd.2003.12.006.
6) Saeki T, Nishi S, Imai N, Ito T, Yamazaki H, Kawano M, et al. Clinicopathological characteristics of patients with IgG4-related tubulointerstitial nephritis. Kidney Int. 2010;78(10):1016-23. doi: 10.1038/ki.2010.271.
7) Takahashi N, Kawashima A, Fletcher JG, Chari ST. Renal involvement in patients with autoimmune pancreatitis: CT and MR imaging findings. Radiology. 2007;242(3):791-801. doi: 10.1148/radiol.2423060003.
8) Khalili K, Doyle DJ, Chawla TP, Hanbidge AE. Renal cortical lesions in patients with autoimmune pancreatitis: a clue to differentiation from pancreatic malignancy. Eur J Radiol. 2008;67(2):329-35. doi: 10.1016/j.ejrad.2007.07.020.
9) Martínez-de-Alegría A, Baleato-González S, García-Figueiras R, Bermúdez-Naveira A, Abdulkader-Nallib I, Díaz-Peromingo JA, et al. IgG4-related Disease from Head to Toe. Radiographics. 2015;35(7):2007-25. doi: 10.1148/rg.357150066.
10) Mahajan VS, Mattoo H, Deshpande V, Pillai SS, Stone JH. IgG4-related disease. Annu Rev Pathol. 2014;9:315-47. doi: 10.1146/annurev-pathol-012513-104708.
11) Martínez-Valle F, Orozco-Gálvez O, Fernández-Codina A. Etiopatogenia, diagnóstico y tratamiento de la enfermedad relacionada con la IgG4. Med Clin (Barc). 2018;151(1):18-25. doi: 10.1016/j.medcli.2017.10.034.
12) Masaki Y, Dong L, Kurose N, Morikawa Y, Yamamoto M, Takahashi H, et al. Proposal for a new clinical entity, IgG4-positive multiorgan lymphoproliferative syndrome: analysis of 64 cases of IgG4-related disorders. Ann Rheum Dis. 2009;68(8):1310-5. doi: 10.1136/ard.2008.089169.
13) Baltar-Martin JM, García-Monteavaro C, Visus-Fernández-de Manzanos T, Parejo-García L. Afectación renal de las enfermedades relacionadas con IgG4. NefroPlus. 2015;7(1):1-10.
14) Takano K, Yamamoto M, Takahashi H, Himi T. Recent advances in knowledge regarding the head and neck manifestations of IgG4-related disease. Auris Nasus Larynx. 2017;44(1):7-17. doi: 10.1016/j.anl.2016.10.011.
15) Stone JR. Aortitis, periaortitis, and retroperitoneal fibrosis, as manifestations of IgG4-related systemic disease. Curr Opin Rheumatol. 2011;23(1):88-94. doi: 10.1097/bor.0b013e3283412f7c.
16) Kuroda N, Nakamura S, Miyazaki K, Inoue K, Ohara M, Mizuno K, et al. Chronic sclerosing pyelitis with an increased number of IgG4-positive plasma cells. Med Mol Morphol. 2009;42(4):236-8. doi: 10.1007/s00795-008-0425-8.
17) Kim SA, Lee SR, Huh J, Shen SS, Ro JY. IgG4-associated inflammatory pseudotumor of ureter: clinicopathologic and immunohistochemical study of 3 cases. Hum Pathol. 2011;42(8):1178-84. doi: 10.1016/j.humpath.2010.03.011.
18) Nakai Y, Kagebayashi Y, Matsumoto Y, Fukui S, Kim Y, Yoshimoto S, et al. IgG4-related prostatitis associated with retroperitoneal fibrosis: a case report. Hinyokika Kiyo. 2013;59(12):781-4.
19) Yamaguchi Y, Kanetsuna Y, Honda K, Yamanaka N, Kawano M, Nagata M, et al. Characteristic tubulointerstitial nephritis in IgG4-related disease. Hum Pathol. 2012;43(4):536-49. doi: 10.1016/j.humpath.2011.06.002.
20) Fernández Lorente L, López Álvarez D, García López V, Abujder Kollros V, Ariza A, Gálvez A, et al. Enfermedad relacionada con IgG4: descripción de un caso con lesiones pulmonares, adenopatías mediastínicas e insuficiencia renal rápidamente progresiva. Nefrología (Madr.). 2015;35(2):218-23.
21) Kawano M, Saeki T, Nakashima H, Nishi S, Yamaguchi Y, Hisano S, et al. Proposal for diagnostic criteria for IgG4-related kidney disease. Clin Exp Nephrol. 2011;15(5):615-26. doi: 10.1007/s10157-011-0521-2.
22) Stone JH, Zen Y, Deshpande V. IgG4-related disease. N Engl J Med. 2012;366(6):539-51. doi: 10.1056/NEJMra1104650.
23) Wallace ZS, Mattoo H, Carruthers M, Vinay S Mahajan VS, Della Torre E, Lee H, et al. Plasmablasts as a biomarker for IgG4-related disease, independent of serum IgG4concentrations. Ann Rheum Dis. 2015;74(1):190-5. doi: 10.1136/annrheumdis-2014-205233.
24) Vasaitis L. IgG4-related disease: A relatively new concept for clinicians. Eur J Intern Med. 2016;27:1-9. doi: 10.1016/j.ejim.2015.09.022.
25) Stone JH, Brito-Zerón P, Bosch X, Ramos-Casals M. Diagnostic approach to the complexity of IgG4-Related disease. Mayo Clin Proc. 2015;90(7):927-39. doi: 10.1016/j.mayocp.2015.03.020.
26) Alexander MP, Larsen CP, Gibson IW, Nasr SH, Sethi S, Fidler ME, et al. Membranous glomerulonephritis is a manifestation of IgG4-related disease. Kidney Int. 2013;83(3):455-62. doi: 10.1038/ki.2012.382.
27) Al Zahrani H, Kyoung Kim T, Khalili K, Vlachou P, Yu H, Jang HJ. IgG4-related disease in the abdomen: a great mimicker. Semin Ultrasound CT MR. 2014;35(3):240-54. doi: 10.1053/j.sult.2013.12.002.
28) Watson SJ, Jenkins DA, Bellamy CO. Nephropathy in IgG4-related systemic disease. Am J Surg Pathol. 2006;30(11):1472-7. doi: 10.1097/01.pas.0000213308.43929.97.
29) Cornell LD, Chicano SL, Deshpande V, Collins AB, Selig MK, Lauwers GY, et al. Pseudotumors due to IgG4 immune-complex tubulointerstitial nephritis associated with autoimmune pancreatocentric disease. Am J Surg Pathol. 2007;31(10):1586-97. doi: 10.1097/PAS.0b013e318059b87c.
30) Kim B, Kim JH, Byun JH, Hyoung Jung Kim HJ, Lee SS, Kim SY, et al. IgG4-related kidney disease: MRI findings with emphasis on the usefulness of diffusion-weighted imaging. Eur J Radiol. 2014;83(7):1057-62. doi: 10.1016/j.ejrad.2014.03.033.
31) Sangha Brar JS, Gupta S, Haja Mohideen SM, Liauw L, Lath N. The pancreatic and extrapancreatic manifestations of IgG4-related disease. Diagn Interv Radiol. 2018;24(2):83-8. doi: 10.5152/dir.2018.17319.
32) Cortés-Romera M, Sabaté-Llobera A, Gámez-Cenzano C, Torras-Ambròs J. Utilidad de la PET/TC en la enfermedad por IgG4. Med Clin (Barc). 2015;145(7):321-2. doi: 10.1016/j.medcli.2014.11.019.
33) Raissian Y, Nasr SH, Larsen CP, Colvin RB, Smyrk TC, Takahashi N, et al. Diagnosis of IgG4-related tubulointerstitial nephritis. J Am Soc Nephrol. 2011;22(7):1343-52. doi: 10.1681/ASN.2011010062.
34) Saeki T, Kawano M. IgG4-related kidney disease [published correction appears in Kidney Int. 2014 Jun;85(6):1472]. Kidney Int. 2014;85(2):251-7. doi: 10.1038/ki.2013.393.
35) Yamaguchi Y, Kanetsuna Y, Honda K, Yamanaka N, Kawano M, Nagata M, et al. Characteristic tubulointerstitial nephritis in IgG4-related disease. Hum Pathol. 2012;43(4):536-49. doi: 10.1016/j.humpath.2011.06.002.
36) Sharma SG, Vlase HL, D'Agati VD. IgG4-related tubulointerstitial nephritis with plasma cell-rich renal arteritis. Am J Kidney Dis. 2013;61(4):638-43. doi: 10.1053/j.ajkd.2012.07.031.
37) Carruthers MN, Stone JH, Khosroshahi A. The latest on IgG4-RD: a rapidly emerging disease. Curr Opin Rheumatol. 2012;24(1):60-9. doi: 10.1097/BOR.0b013e32834ddb4a.
38) Okazaki K, Uchida K, Miyoshi H, Ikeura T, Takaoka M, Nishio A. Recent concepts of autoimmune pancreatitis and IgG4-related disease. Clin Rev Allergy Immunol. 2011;41(2):126-38. doi: 10.1007/s12016-010-8214-2.
39) Okazaki K, Uchida K, Koyabu M, Miyoshi H, Takaoka M. Recent advances in the concept and diagnosis of autoimmune pancreatitis and IgG4-related disease. J Gastroenterol. 2011;46(3):277-88. doi: 10.1007/s00535-011-0386-x.
40) Iaccarino L, Talarico R, Scirè CA, Amoura Z, Burmester G, Doria A, et al. IgG4-related diseases: state of the art on clinical practice guidelines. RMD Open. 2019;4(Suppl. 1):e000787. doi: 10.1136/rmdopen-2018-000787.
2) Kamisawa T, Zen Y, Pillai S, Stone JH. IgG4-related disease. Lancet. 2015;385(9976):1460-71. doi: 10.1016/S0140-6736(14)60720-0.
3) Yoshida K, Toki F, Takeuchi T, Watanabe S, Shiratori K, Hayashi N. Chronic pancreatitis caused by an autoimmune abnormality. Proposal of the concept of autoimmune pancreatitis. Dig Dis Sci. 1995;40(7):1561-8. doi: 10.1007/BF02285209.
4) Deshpande V, Zen Y, Chan JK, Yi EE, Sato Y, Yoshino T, et al. Consensus statement on the pathology of IgG4-related disease. Mod Pathol. 2012;25(9):1181-92. doi: 10.1038/modpathol.2012.72.
5) Uchiyama-Tanaka Y, Mori Y, Kimura T, Sonomura K, Umemura S, Kishimoto N, et al. Acute tubulointerstitial nephritis associated with autoimmune-related pancreatitis. Am J Kidney Dis. 2004;43(3):e18-e25. doi: 10.1053/j.ajkd.2003.12.006.
6) Saeki T, Nishi S, Imai N, Ito T, Yamazaki H, Kawano M, et al. Clinicopathological characteristics of patients with IgG4-related tubulointerstitial nephritis. Kidney Int. 2010;78(10):1016-23. doi: 10.1038/ki.2010.271.
7) Takahashi N, Kawashima A, Fletcher JG, Chari ST. Renal involvement in patients with autoimmune pancreatitis: CT and MR imaging findings. Radiology. 2007;242(3):791-801. doi: 10.1148/radiol.2423060003.
8) Khalili K, Doyle DJ, Chawla TP, Hanbidge AE. Renal cortical lesions in patients with autoimmune pancreatitis: a clue to differentiation from pancreatic malignancy. Eur J Radiol. 2008;67(2):329-35. doi: 10.1016/j.ejrad.2007.07.020.
9) Martínez-de-Alegría A, Baleato-González S, García-Figueiras R, Bermúdez-Naveira A, Abdulkader-Nallib I, Díaz-Peromingo JA, et al. IgG4-related Disease from Head to Toe. Radiographics. 2015;35(7):2007-25. doi: 10.1148/rg.357150066.
10) Mahajan VS, Mattoo H, Deshpande V, Pillai SS, Stone JH. IgG4-related disease. Annu Rev Pathol. 2014;9:315-47. doi: 10.1146/annurev-pathol-012513-104708.
11) Martínez-Valle F, Orozco-Gálvez O, Fernández-Codina A. Etiopatogenia, diagnóstico y tratamiento de la enfermedad relacionada con la IgG4. Med Clin (Barc). 2018;151(1):18-25. doi: 10.1016/j.medcli.2017.10.034.
12) Masaki Y, Dong L, Kurose N, Morikawa Y, Yamamoto M, Takahashi H, et al. Proposal for a new clinical entity, IgG4-positive multiorgan lymphoproliferative syndrome: analysis of 64 cases of IgG4-related disorders. Ann Rheum Dis. 2009;68(8):1310-5. doi: 10.1136/ard.2008.089169.
13) Baltar-Martin JM, García-Monteavaro C, Visus-Fernández-de Manzanos T, Parejo-García L. Afectación renal de las enfermedades relacionadas con IgG4. NefroPlus. 2015;7(1):1-10.
14) Takano K, Yamamoto M, Takahashi H, Himi T. Recent advances in knowledge regarding the head and neck manifestations of IgG4-related disease. Auris Nasus Larynx. 2017;44(1):7-17. doi: 10.1016/j.anl.2016.10.011.
15) Stone JR. Aortitis, periaortitis, and retroperitoneal fibrosis, as manifestations of IgG4-related systemic disease. Curr Opin Rheumatol. 2011;23(1):88-94. doi: 10.1097/bor.0b013e3283412f7c.
16) Kuroda N, Nakamura S, Miyazaki K, Inoue K, Ohara M, Mizuno K, et al. Chronic sclerosing pyelitis with an increased number of IgG4-positive plasma cells. Med Mol Morphol. 2009;42(4):236-8. doi: 10.1007/s00795-008-0425-8.
17) Kim SA, Lee SR, Huh J, Shen SS, Ro JY. IgG4-associated inflammatory pseudotumor of ureter: clinicopathologic and immunohistochemical study of 3 cases. Hum Pathol. 2011;42(8):1178-84. doi: 10.1016/j.humpath.2010.03.011.
18) Nakai Y, Kagebayashi Y, Matsumoto Y, Fukui S, Kim Y, Yoshimoto S, et al. IgG4-related prostatitis associated with retroperitoneal fibrosis: a case report. Hinyokika Kiyo. 2013;59(12):781-4.
19) Yamaguchi Y, Kanetsuna Y, Honda K, Yamanaka N, Kawano M, Nagata M, et al. Characteristic tubulointerstitial nephritis in IgG4-related disease. Hum Pathol. 2012;43(4):536-49. doi: 10.1016/j.humpath.2011.06.002.
20) Fernández Lorente L, López Álvarez D, García López V, Abujder Kollros V, Ariza A, Gálvez A, et al. Enfermedad relacionada con IgG4: descripción de un caso con lesiones pulmonares, adenopatías mediastínicas e insuficiencia renal rápidamente progresiva. Nefrología (Madr.). 2015;35(2):218-23.
21) Kawano M, Saeki T, Nakashima H, Nishi S, Yamaguchi Y, Hisano S, et al. Proposal for diagnostic criteria for IgG4-related kidney disease. Clin Exp Nephrol. 2011;15(5):615-26. doi: 10.1007/s10157-011-0521-2.
22) Stone JH, Zen Y, Deshpande V. IgG4-related disease. N Engl J Med. 2012;366(6):539-51. doi: 10.1056/NEJMra1104650.
23) Wallace ZS, Mattoo H, Carruthers M, Vinay S Mahajan VS, Della Torre E, Lee H, et al. Plasmablasts as a biomarker for IgG4-related disease, independent of serum IgG4concentrations. Ann Rheum Dis. 2015;74(1):190-5. doi: 10.1136/annrheumdis-2014-205233.
24) Vasaitis L. IgG4-related disease: A relatively new concept for clinicians. Eur J Intern Med. 2016;27:1-9. doi: 10.1016/j.ejim.2015.09.022.
25) Stone JH, Brito-Zerón P, Bosch X, Ramos-Casals M. Diagnostic approach to the complexity of IgG4-Related disease. Mayo Clin Proc. 2015;90(7):927-39. doi: 10.1016/j.mayocp.2015.03.020.
26) Alexander MP, Larsen CP, Gibson IW, Nasr SH, Sethi S, Fidler ME, et al. Membranous glomerulonephritis is a manifestation of IgG4-related disease. Kidney Int. 2013;83(3):455-62. doi: 10.1038/ki.2012.382.
27) Al Zahrani H, Kyoung Kim T, Khalili K, Vlachou P, Yu H, Jang HJ. IgG4-related disease in the abdomen: a great mimicker. Semin Ultrasound CT MR. 2014;35(3):240-54. doi: 10.1053/j.sult.2013.12.002.
28) Watson SJ, Jenkins DA, Bellamy CO. Nephropathy in IgG4-related systemic disease. Am J Surg Pathol. 2006;30(11):1472-7. doi: 10.1097/01.pas.0000213308.43929.97.
29) Cornell LD, Chicano SL, Deshpande V, Collins AB, Selig MK, Lauwers GY, et al. Pseudotumors due to IgG4 immune-complex tubulointerstitial nephritis associated with autoimmune pancreatocentric disease. Am J Surg Pathol. 2007;31(10):1586-97. doi: 10.1097/PAS.0b013e318059b87c.
30) Kim B, Kim JH, Byun JH, Hyoung Jung Kim HJ, Lee SS, Kim SY, et al. IgG4-related kidney disease: MRI findings with emphasis on the usefulness of diffusion-weighted imaging. Eur J Radiol. 2014;83(7):1057-62. doi: 10.1016/j.ejrad.2014.03.033.
31) Sangha Brar JS, Gupta S, Haja Mohideen SM, Liauw L, Lath N. The pancreatic and extrapancreatic manifestations of IgG4-related disease. Diagn Interv Radiol. 2018;24(2):83-8. doi: 10.5152/dir.2018.17319.
32) Cortés-Romera M, Sabaté-Llobera A, Gámez-Cenzano C, Torras-Ambròs J. Utilidad de la PET/TC en la enfermedad por IgG4. Med Clin (Barc). 2015;145(7):321-2. doi: 10.1016/j.medcli.2014.11.019.
33) Raissian Y, Nasr SH, Larsen CP, Colvin RB, Smyrk TC, Takahashi N, et al. Diagnosis of IgG4-related tubulointerstitial nephritis. J Am Soc Nephrol. 2011;22(7):1343-52. doi: 10.1681/ASN.2011010062.
34) Saeki T, Kawano M. IgG4-related kidney disease [published correction appears in Kidney Int. 2014 Jun;85(6):1472]. Kidney Int. 2014;85(2):251-7. doi: 10.1038/ki.2013.393.
35) Yamaguchi Y, Kanetsuna Y, Honda K, Yamanaka N, Kawano M, Nagata M, et al. Characteristic tubulointerstitial nephritis in IgG4-related disease. Hum Pathol. 2012;43(4):536-49. doi: 10.1016/j.humpath.2011.06.002.
36) Sharma SG, Vlase HL, D'Agati VD. IgG4-related tubulointerstitial nephritis with plasma cell-rich renal arteritis. Am J Kidney Dis. 2013;61(4):638-43. doi: 10.1053/j.ajkd.2012.07.031.
37) Carruthers MN, Stone JH, Khosroshahi A. The latest on IgG4-RD: a rapidly emerging disease. Curr Opin Rheumatol. 2012;24(1):60-9. doi: 10.1097/BOR.0b013e32834ddb4a.
38) Okazaki K, Uchida K, Miyoshi H, Ikeura T, Takaoka M, Nishio A. Recent concepts of autoimmune pancreatitis and IgG4-related disease. Clin Rev Allergy Immunol. 2011;41(2):126-38. doi: 10.1007/s12016-010-8214-2.
39) Okazaki K, Uchida K, Koyabu M, Miyoshi H, Takaoka M. Recent advances in the concept and diagnosis of autoimmune pancreatitis and IgG4-related disease. J Gastroenterol. 2011;46(3):277-88. doi: 10.1007/s00535-011-0386-x.
40) Iaccarino L, Talarico R, Scirè CA, Amoura Z, Burmester G, Doria A, et al. IgG4-related diseases: state of the art on clinical practice guidelines. RMD Open. 2019;4(Suppl. 1):e000787. doi: 10.1136/rmdopen-2018-000787.
Published
2020-12-15
How to Cite
1.
Sánchez Oro R, Alonso Muñóz EM. Inmunoglobulin G4-related kidney disease. Rev Nefrol Dial Traspl. [Internet]. 2020Dec.15 [cited 2024Jul.27];40(4):341-8. Available from: http://revistarenal.org.ar/index.php/rndt/article/view/577
Section
Review Article
Copyright (c) 2020 Revista de Nefrología, Diálisis y Trasplante
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
