The relationship between serum dentin matrix Acidic Phosphoprotein-1, Sortilin levels and arterial stiffness in hemodialysis patients

Abstract

Introduction: The most important cause of death in hemodialysis (HD) patients is cardiovascular system disease. Dentin Matrix Acidic Phosphoprotein-1 (DMP-1) and sortilin are two molecules associated with cardiovascular events; their significance in HD patients is unknown. In this study, we aimed to investigate the relationship between serum DMP-1 and sortilin levels and arterial stiffness in HD patients. Materials and Methods: A total of 80 individuals, 60 HD patients, and 20 healthy controls were included in the study. Arterial stiffness measurements were performed non-invasively with the Mobil-O-Graph device. Serum DMP-1 and sortilin were measured using the ELISA method in blood samples taken before dialysis. Results: DMP-1 was higher in HD patients than in the healthy controls. Patients with a Pulse Wave Velocity (PWV) value ≥10 were considered to have increased arterial stiffness. Patients with increased arterial stiffness were older, had higher body mass index (BMI) and systolic blood pressure (SBP), and lower creatinine and DMP-1. In the correlation analysis, PWV was positively correlated with age, BMI, and SBP and inversely correlated with creatinine and DMP-1. DMP-1 was negatively correlated with age and C-reactive protein (CRP). In the regression analysis, SBP and DMP-1 were found to be factors affecting PWV. Conclusion: Our study is the first to investigate the relationship between serum DMP-1 and arterial stiffness in HD patients. As a result of our study, we found that serum DMP-1 was inversely related to arterial stiffness in HD patients, and serum sortilin was unrelated.